Detailed information of TA system TA026396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2371623..2372269
• Replicon: chromosome
• Accession: NC_017265
• Organism: Yersinia pestis biovar Medievalis str. Harbin 35

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A3G5L3F2
• Locus tag: YPC_RS11105
• Protein ID: WP_002214976.1
• Coordinates: 2371623..2371805 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0U1R391
• Locus tag: YPC_RS11110
• Protein ID: WP_002211129.1
• Coordinates: 2371850..2372269 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPC_RS11070	2367009..2367479	+	471	WP_002227961.1	flagellar basal body-associated protein FliL	-
YPC_RS11075	2367485..2368486	+	1002	WP_002211135.1	flagellar motor switch protein FliM	-
YPC_RS11080	2368483..2368899	+	417	WP_002211134.1	flagellar motor switch protein FliN	-
YPC_RS11085	2368899..2369435	+	537	WP_002211133.1	flagellar biosynthetic protein FliO	-
YPC_RS11090	2369516..2370256	+	741	WP_002220494.1	flagellar type III secretion system pore protein FliP	-
YPC_RS11095	2370362..2370631	+	270	WP_002211131.1	flagellar biosynthesis protein FliQ	-
YPC_RS11100	2370634..2371416	+	783	WP_002211130.1	flagellar type III secretion system protein FliR	-
YPC_RS11105	2371623..2371805	+	183	WP_002214976.1	type II toxin-antitoxin system HicA family toxin	Toxin
YPC_RS11110	2371850..2372269	+	420	WP_002211129.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
YPC_RS11115	2372527..2373486	-	960	WP_002223882.1	sugar kinase	-
YPC_RS11120	2373535..2374556	-	1022	Protein_2088	ABC transporter permease	-
YPC_RS11125	2374559..2376136	-	1578	WP_002211126.1	sugar ABC transporter ATP-binding protein	-
YPC_RS11130	2376202..2377197	-	996	WP_002211125.1	substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-131)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6783.99 Da
• Isoelectric Point: 10.8877

>T26396 WP_002214976.1 NC_017265:2371623-2371805 [Yersinia pestis biovar Medievalis str. Harbin 35]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Nucleotide

• Length: 183 bp

>T26396 NC_017265:2371623-2371805 [Yersinia pestis biovar Medievalis str. Harbin 35]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15549.42 Da
• Isoelectric Point: 4.7731

>AT26396 WP_002211129.1 NC_017265:2371850-2372269 [Yersinia pestis biovar Medievalis str. Harbin 35]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Nucleotide

• Length: 420 bp

>AT26396 NC_017265:2371850-2372269 [Yersinia pestis biovar Medievalis str. Harbin 35]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Structures

Toxin

• AlphaFold DB: A0A3G5L3F2

Antitoxin

• AlphaFold DB: A0A0U1R391