Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4599934..4600550 Replicon chromosome
Accession NZ_CP110534
Organism Enterobacter roggenkampii strain WS28-4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OM420_RS21705 Protein ID WP_084832108.1
Coordinates 4599934..4600305 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag OM420_RS21710 Protein ID WP_015569912.1
Coordinates 4600308..4600550 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM420_RS21690 (OM420_21680) 4597434..4598336 + 903 WP_008501831.1 formate dehydrogenase subunit beta -
OM420_RS21695 (OM420_21685) 4598333..4598968 + 636 WP_008501832.1 formate dehydrogenase cytochrome b556 subunit -
OM420_RS21700 (OM420_21690) 4598965..4599894 + 930 WP_025912306.1 formate dehydrogenase accessory protein FdhE -
OM420_RS21705 (OM420_21695) 4599934..4600305 - 372 WP_084832108.1 type II toxin-antitoxin system VapC family toxin Toxin
OM420_RS21710 (OM420_21700) 4600308..4600550 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
OM420_RS21715 (OM420_21705) 4600749..4601669 + 921 WP_094945022.1 alpha/beta hydrolase -
OM420_RS21720 (OM420_21710) 4601678..4602619 - 942 WP_023326334.1 fatty acid biosynthesis protein FabY -
OM420_RS21725 (OM420_21715) 4602664..4603101 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
OM420_RS21730 (OM420_21720) 4603098..4603979 - 882 WP_021242790.1 virulence factor BrkB family protein -
OM420_RS21735 (OM420_21725) 4603973..4604572 - 600 WP_008501839.1 glucose-1-phosphatase -
OM420_RS21740 (OM420_21730) 4604661..4605164 - 504 WP_225828756.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13686.79 Da        Isoelectric Point: 6.3290

>T263951 WP_084832108.1 NZ_CP110534:c4600305-4599934 [Enterobacter roggenkampii]
MEHMAVFDTNILIDLFNNRVEAADAIENTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLVSRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT263951 WP_015569912.1 NZ_CP110534:c4600550-4600308 [Enterobacter roggenkampii]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References