Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1946070..1947036 Replicon chromosome
Accession NC_017265
Organism Yersinia pestis biovar Medievalis str. Harbin 35

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag YPC_RS08955 Protein ID WP_002210981.1
Coordinates 1946578..1947036 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag YPC_RS08950 Protein ID WP_002210982.1
Coordinates 1946070..1946516 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPC_RS08930 1941673..1942647 - 975 WP_015683616.1 L-Ala-D/L-Glu epimerase -
YPC_RS08935 1942810..1943313 + 504 WP_002210984.1 thiol peroxidase -
YPC_RS08940 1943566..1944024 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
YPC_RS08945 1944171..1945748 - 1578 WP_002210983.1 transcriptional regulator TyrR -
YPC_RS08950 1946070..1946516 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
YPC_RS08955 1946578..1947036 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
YPC_RS08960 1947046..1948107 - 1062 WP_002210980.1 YcjF family protein -
YPC_RS08965 1948104..1949501 - 1398 WP_002210979.1 YcjX family protein -
YPC_RS08970 1949482..1949724 - 243 WP_002216375.1 phage shock protein PspD -
YPC_RS08975 1949809..1950168 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
YPC_RS08980 1950168..1950395 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
YPC_RS08985 1950557..1951222 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1943566..1944024 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T26395 WP_002210981.1 NC_017265:1946578-1947036 [Yersinia pestis biovar Medievalis str. Harbin 35]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T26395 NC_017265:1946578-1947036 [Yersinia pestis biovar Medievalis str. Harbin 35]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT26395 WP_002210982.1 NC_017265:1946070-1946516 [Yersinia pestis biovar Medievalis str. Harbin 35]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT26395 NC_017265:1946070-1946516 [Yersinia pestis biovar Medievalis str. Harbin 35]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References