Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1660750..1661547 Replicon chromosome
Accession NZ_CP110534
Organism Enterobacter roggenkampii strain WS28-4

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag OM420_RS07790 Protein ID WP_032651255.1
Coordinates 1661026..1661547 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag OM420_RS07785 Protein ID WP_008499829.1
Coordinates 1660750..1661019 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM420_RS07750 (OM420_07745) 1656375..1656761 + 387 WP_240515174.1 Tox-REase-5 domain-containing protein -
OM420_RS07755 (OM420_07750) 1657098..1657472 + 375 WP_240515172.1 Imm52 family immunity protein -
OM420_RS07760 (OM420_07755) 1657473..1658150 + 678 Protein_1506 contractile injection system protein, VgrG/Pvc8 family -
OM420_RS07765 (OM420_07760) 1658246..1658473 - 228 WP_008499832.1 YccJ family protein -
OM420_RS07770 (OM420_07765) 1658494..1659090 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
OM420_RS07775 (OM420_07770) 1659482..1659652 + 171 WP_013097201.1 general stress protein -
OM420_RS07780 (OM420_07775) 1659771..1660688 + 918 WP_023292825.1 DMT family transporter -
OM420_RS07785 (OM420_07780) 1660750..1661019 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
OM420_RS07790 (OM420_07785) 1661026..1661547 + 522 WP_032651255.1 GNAT family N-acetyltransferase Toxin
OM420_RS07795 (OM420_07790) 1661621..1662943 - 1323 WP_094943645.1 pyrimidine utilization transport protein G -
OM420_RS07800 (OM420_07795) 1662965..1663459 - 495 WP_094943642.1 pyrimidine utilization flavin reductase protein F -
OM420_RS07805 (OM420_07800) 1663469..1664059 - 591 WP_023327079.1 malonic semialdehyde reductase -
OM420_RS07810 (OM420_07805) 1664069..1664869 - 801 WP_094943639.1 pyrimidine utilization protein D -
OM420_RS07815 (OM420_07810) 1664877..1665263 - 387 WP_008499822.1 pyrimidine utilization protein C -
OM420_RS07820 (OM420_07815) 1665275..1665964 - 690 WP_047745127.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1651527..1662943 11416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T263944 WP_032651255.1 NZ_CP110534:1661026-1661547 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT263944 WP_008499829.1 NZ_CP110534:1660750-1661019 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155TD66

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References