Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1054979..1055599 Replicon chromosome
Accession NZ_CP110534
Organism Enterobacter roggenkampii strain WS28-4

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OM420_RS04910 Protein ID WP_008499287.1
Coordinates 1054979..1055197 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OM420_RS04915 Protein ID WP_008499288.1
Coordinates 1055225..1055599 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM420_RS04880 (OM420_04880) 1050992..1051252 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
OM420_RS04885 (OM420_04885) 1051255..1051395 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OM420_RS04890 (OM420_04890) 1051392..1052102 - 711 WP_021241637.1 GNAT family protein -
OM420_RS04895 (OM420_04895) 1052204..1053664 + 1461 WP_008499284.1 PLP-dependent aminotransferase family protein -
OM420_RS04900 (OM420_04900) 1053636..1054103 - 468 WP_059362219.1 YlaC family protein -
OM420_RS04905 (OM420_04905) 1054221..1054772 - 552 WP_045416680.1 maltose O-acetyltransferase -
OM420_RS04910 (OM420_04910) 1054979..1055197 - 219 WP_008499287.1 HHA domain-containing protein Toxin
OM420_RS04915 (OM420_04915) 1055225..1055599 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OM420_RS04920 (OM420_04920) 1056109..1059255 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
OM420_RS04925 (OM420_04925) 1059278..1060471 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T263943 WP_008499287.1 NZ_CP110534:c1055197-1054979 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT263943 WP_008499288.1 NZ_CP110534:c1055599-1055225 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References