Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4637282..4637898 Replicon chromosome
Accession NZ_CP110533
Organism Enterobacter quasiroggenkampii strain WS12-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OM418_RS21935 Protein ID WP_277718195.1
Coordinates 4637282..4637653 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1H8XBY4
Locus tag OM418_RS21940 Protein ID WP_045909092.1
Coordinates 4637656..4637898 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM418_RS21920 (OM418_21920) 4634782..4635684 + 903 WP_277718193.1 formate dehydrogenase subunit beta -
OM418_RS21925 (OM418_21925) 4635681..4636316 + 636 WP_008501832.1 formate dehydrogenase cytochrome b556 subunit -
OM418_RS21930 (OM418_21930) 4636313..4637242 + 930 WP_277718194.1 formate dehydrogenase accessory protein FdhE -
OM418_RS21935 (OM418_21935) 4637282..4637653 - 372 WP_277718195.1 type II toxin-antitoxin system VapC family toxin Toxin
OM418_RS21940 (OM418_21940) 4637656..4637898 - 243 WP_045909092.1 ribbon-helix-helix protein, CopG family Antitoxin
OM418_RS21945 (OM418_21945) 4638097..4639017 + 921 WP_252074188.1 alpha/beta hydrolase -
OM418_RS21950 (OM418_21950) 4639026..4639967 - 942 WP_023309755.1 fatty acid biosynthesis protein FabY -
OM418_RS21955 (OM418_21955) 4640012..4640449 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
OM418_RS21960 (OM418_21960) 4640446..4641327 - 882 WP_277718196.1 virulence factor BrkB family protein -
OM418_RS21965 (OM418_21965) 4641321..4641920 - 600 WP_045909089.1 glucose-1-phosphatase -
OM418_RS21970 (OM418_21970) 4642326..4642805 + 480 WP_277718197.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13656.80 Da        Isoelectric Point: 6.9790

>T263939 WP_277718195.1 NZ_CP110533:c4637653-4637282 [Enterobacter quasiroggenkampii]
MEHMAVFDTNILIDLFNNRVEAANTIENTASHRSISLITWMEVMVGARKHGHEAKTAAVMGAFEVIDVTREIAERSVVLR
EKHGMKLPDAIILATAQSRNCPLVTRNTKDFQGIAGVVLPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.63 Da        Isoelectric Point: 4.2584

>AT263939 WP_045909092.1 NZ_CP110533:c4637898-4637656 [Enterobacter quasiroggenkampii]
MSLLAELNMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H8XBY4

References