Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 1685960..1686757 Replicon chromosome
Accession NZ_CP110533
Organism Enterobacter quasiroggenkampii strain WS12-3

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag OM418_RS07850 Protein ID WP_262790460.1
Coordinates 1686236..1686757 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag OM418_RS07845 Protein ID WP_008499829.1
Coordinates 1685960..1686229 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM418_RS07815 (OM418_07815) 1681586..1682029 - 444 WP_277718586.1 helix-turn-helix domain-containing protein -
OM418_RS07820 (OM418_07820) 1682182..1683423 + 1242 WP_277718587.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
OM418_RS07825 (OM418_07825) 1683457..1683684 - 228 WP_008499832.1 YccJ family protein -
OM418_RS07830 (OM418_07830) 1683705..1684301 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
OM418_RS07835 (OM418_07835) 1684693..1684863 + 171 WP_023311077.1 general stress protein -
OM418_RS07840 (OM418_07840) 1684981..1685898 + 918 WP_069719465.1 DMT family transporter -
OM418_RS07845 (OM418_07845) 1685960..1686229 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
OM418_RS07850 (OM418_07850) 1686236..1686757 + 522 WP_262790460.1 GNAT family N-acetyltransferase Toxin
OM418_RS07855 (OM418_07855) 1686831..1688153 - 1323 WP_277718588.1 pyrimidine utilization transport protein G -
OM418_RS07860 (OM418_07860) 1688175..1688669 - 495 WP_023327078.1 pyrimidine utilization flavin reductase protein F -
OM418_RS07865 (OM418_07865) 1688679..1689269 - 591 WP_023327079.1 malonic semialdehyde reductase -
OM418_RS07870 (OM418_07870) 1689279..1690079 - 801 WP_045908309.1 pyrimidine utilization protein D -
OM418_RS07875 (OM418_07875) 1690087..1690473 - 387 WP_008499822.1 pyrimidine utilization protein C -
OM418_RS07880 (OM418_07880) 1690485..1691174 - 690 WP_045908308.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19797.60 Da        Isoelectric Point: 8.4707

>T263932 WP_262790460.1 NZ_CP110533:1686236-1686757 [Enterobacter quasiroggenkampii]
VENLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSRTQQR
RIPYSNVPSVTLGRLAIHKDLQGQEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDRAKRFYLKQGFIPLTGENSHSLF
FPTKSIERLFEQV

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT263932 WP_008499829.1 NZ_CP110533:1685960-1686229 [Enterobacter quasiroggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References