Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1076174..1076794 Replicon chromosome
Accession NZ_CP110533
Organism Enterobacter quasiroggenkampii strain WS12-3

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OM418_RS04980 Protein ID WP_008499287.1
Coordinates 1076174..1076392 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OM418_RS04985 Protein ID WP_008499288.1
Coordinates 1076420..1076794 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM418_RS04950 (OM418_04950) 1072185..1072445 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
OM418_RS04955 (OM418_04955) 1072448..1072588 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OM418_RS04960 (OM418_04960) 1072585..1073295 - 711 WP_111967303.1 GNAT family protein -
OM418_RS04965 (OM418_04965) 1073397..1074857 + 1461 WP_111967304.1 PLP-dependent aminotransferase family protein -
OM418_RS04970 (OM418_04970) 1074829..1075296 - 468 WP_045909756.1 YlaC family protein -
OM418_RS04975 (OM418_04975) 1075414..1075965 - 552 WP_045909755.1 maltose O-acetyltransferase -
OM418_RS04980 (OM418_04980) 1076174..1076392 - 219 WP_008499287.1 HHA domain-containing protein Toxin
OM418_RS04985 (OM418_04985) 1076420..1076794 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OM418_RS04990 (OM418_04990) 1077303..1080449 - 3147 WP_045909754.1 multidrug efflux RND transporter permease subunit AcrB -
OM418_RS04995 (OM418_04995) 1080472..1081665 - 1194 WP_045909753.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T263931 WP_008499287.1 NZ_CP110533:c1076392-1076174 [Enterobacter quasiroggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT263931 WP_008499288.1 NZ_CP110533:c1076794-1076420 [Enterobacter quasiroggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References