Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 261420..262016 Replicon chromosome
Accession NZ_CP110533
Organism Enterobacter quasiroggenkampii strain WS12-3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag OM418_RS01175 Protein ID WP_214598992.1
Coordinates 261714..262016 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag OM418_RS01170 Protein ID WP_021242718.1
Coordinates 261420..261707 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM418_RS01165 (OM418_01165) 259792..261423 + 1632 WP_277718270.1 Na/Pi cotransporter family protein -
OM418_RS01170 (OM418_01170) 261420..261707 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
OM418_RS01175 (OM418_01175) 261714..262016 - 303 WP_214598992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM418_RS01180 (OM418_01180) 262214..263086 + 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
OM418_RS01185 (OM418_01185) 263087..263359 - 273 WP_014830263.1 DUF3811 domain-containing protein -
OM418_RS01190 (OM418_01190) 263410..264354 - 945 WP_045909140.1 ketopantoate/pantoate/pantothenate transporter PanS -
OM418_RS01195 (OM418_01195) 264460..266034 - 1575 WP_277718271.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11399.20 Da        Isoelectric Point: 10.0577

>T263930 WP_214598992.1 NZ_CP110533:c262016-261714 [Enterobacter quasiroggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT263930 WP_021242718.1 NZ_CP110533:c261707-261420 [Enterobacter quasiroggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References