Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3834022..3834679 Replicon chromosome
Accession NZ_CP110532
Organism Enterobacter roggenkampii strain ws6-3

Toxin (Protein)


Gene name cptA Uniprot ID W7P4L3
Locus tag OM095_RS18330 Protein ID WP_023326024.1
Coordinates 3834022..3834432 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag OM095_RS18335 Protein ID WP_006178375.1
Coordinates 3834413..3834679 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM095_RS18310 (OM095_18300) 3830015..3831748 - 1734 WP_095428707.1 single-stranded-DNA-specific exonuclease RecJ -
OM095_RS18315 (OM095_18305) 3831754..3832467 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OM095_RS18320 (OM095_18310) 3832496..3833392 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
OM095_RS18325 (OM095_18315) 3833494..3834015 + 522 WP_008499710.1 flavodoxin FldB -
OM095_RS18330 (OM095_18320) 3834022..3834432 - 411 WP_023326024.1 protein YgfX Toxin
OM095_RS18335 (OM095_18325) 3834413..3834679 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
OM095_RS18340 (OM095_18330) 3834974..3835954 + 981 WP_045335240.1 tRNA-modifying protein YgfZ -
OM095_RS18345 (OM095_18335) 3836039..3836698 - 660 WP_021242052.1 hemolysin III family protein -
OM095_RS18350 (OM095_18340) 3836964..3837695 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
OM095_RS18355 (OM095_18345) 3837812..3839245 + 1434 WP_095428708.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16063.06 Da        Isoelectric Point: 10.9468

>T263928 WP_023326024.1 NZ_CP110532:c3834432-3834022 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT263928 WP_006178375.1 NZ_CP110532:c3834679-3834413 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W7P4L3

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References