Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1699805..1700602 Replicon chromosome
Accession NZ_CP110532
Organism Enterobacter roggenkampii strain ws6-3

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag OM095_RS08085 Protein ID WP_039023897.1
Coordinates 1700081..1700602 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag OM095_RS08080 Protein ID WP_008499829.1
Coordinates 1699805..1700074 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM095_RS08050 (OM095_08040) 1695431..1695874 - 444 WP_095428627.1 helix-turn-helix domain-containing protein -
OM095_RS08055 (OM095_08045) 1696027..1697268 + 1242 WP_095428626.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
OM095_RS08060 (OM095_08050) 1697302..1697529 - 228 WP_008499832.1 YccJ family protein -
OM095_RS08065 (OM095_08055) 1697548..1698144 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
OM095_RS08070 (OM095_08060) 1698536..1698706 + 171 WP_013097201.1 general stress protein -
OM095_RS08075 (OM095_08065) 1698826..1699743 + 918 WP_095428625.1 DMT family transporter -
OM095_RS08080 (OM095_08070) 1699805..1700074 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
OM095_RS08085 (OM095_08075) 1700081..1700602 + 522 WP_039023897.1 GNAT family N-acetyltransferase Toxin
OM095_RS08090 (OM095_08080) 1700676..1701998 - 1323 WP_095428624.1 pyrimidine utilization transport protein G -
OM095_RS08095 (OM095_08085) 1702020..1702514 - 495 WP_023292823.1 pyrimidine utilization flavin reductase protein F -
OM095_RS08100 (OM095_08090) 1702524..1703114 - 591 WP_095428623.1 malonic semialdehyde reductase -
OM095_RS08105 (OM095_08095) 1703124..1703924 - 801 WP_021240807.1 pyrimidine utilization protein D -
OM095_RS08110 (OM095_08100) 1703932..1704318 - 387 WP_008499822.1 pyrimidine utilization protein C -
OM095_RS08115 (OM095_08105) 1704330..1705019 - 690 WP_095428622.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19713.48 Da        Isoelectric Point: 7.4313

>T263923 WP_039023897.1 NZ_CP110532:1700081-1700602 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYNFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT263923 WP_008499829.1 NZ_CP110532:1699805-1700074 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References