Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1058265..1058885 Replicon chromosome
Accession NZ_CP110532
Organism Enterobacter roggenkampii strain ws6-3

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OM095_RS04950 Protein ID WP_008499287.1
Coordinates 1058265..1058483 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OM095_RS04955 Protein ID WP_008499288.1
Coordinates 1058511..1058885 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM095_RS04920 (OM095_04920) 1054278..1054538 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
OM095_RS04925 (OM095_04925) 1054541..1054681 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OM095_RS04930 (OM095_04930) 1054678..1055388 - 711 WP_065101748.1 GNAT family protein -
OM095_RS04935 (OM095_04935) 1055490..1056950 + 1461 WP_277715273.1 PLP-dependent aminotransferase family protein -
OM095_RS04940 (OM095_04940) 1056922..1057389 - 468 WP_008499285.1 YlaC family protein -
OM095_RS04945 (OM095_04945) 1057507..1058058 - 552 WP_008499286.1 maltose O-acetyltransferase -
OM095_RS04950 (OM095_04950) 1058265..1058483 - 219 WP_008499287.1 HHA domain-containing protein Toxin
OM095_RS04955 (OM095_04955) 1058511..1058885 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OM095_RS04960 (OM095_04960) 1059395..1062541 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
OM095_RS04965 (OM095_04965) 1062564..1063757 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T263922 WP_008499287.1 NZ_CP110532:c1058483-1058265 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT263922 WP_008499288.1 NZ_CP110532:c1058885-1058511 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References