Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 143873..144480 Replicon chromosome
Accession NZ_CP110532
Organism Enterobacter roggenkampii strain ws6-3

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag OM095_RS00650 Protein ID WP_071993467.1
Coordinates 143873..144058 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A155E9Y3
Locus tag OM095_RS00655 Protein ID WP_032675741.1
Coordinates 144073..144480 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM095_RS00635 (OM095_00635) 140287..141825 + 1539 WP_023345218.1 aldehyde dehydrogenase AldB -
OM095_RS00640 (OM095_00640) 141822..142784 - 963 WP_008502735.1 LysR family transcriptional regulator -
OM095_RS00645 (OM095_00645) 142905..143663 + 759 WP_095428897.1 MipA/OmpV family protein -
OM095_RS00650 (OM095_00650) 143873..144058 + 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
OM095_RS00655 (OM095_00655) 144073..144480 + 408 WP_032675741.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OM095_RS00660 (OM095_00660) 144484..145560 - 1077 WP_032654523.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
OM095_RS00665 (OM095_00665) 145906..146601 - 696 WP_095428898.1 L-ribulose-5-phosphate 4-epimerase -
OM095_RS00670 (OM095_00670) 146595..147455 - 861 WP_021242445.1 L-ribulose-5-phosphate 3-epimerase -
OM095_RS00675 (OM095_00675) 147458..148111 - 654 WP_032654530.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T263920 WP_071993467.1 NZ_CP110532:143873-144058 [Enterobacter roggenkampii]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15010.78 Da        Isoelectric Point: 4.3897

>AT263920 WP_032675741.1 NZ_CP110532:144073-144480 [Enterobacter roggenkampii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDNALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure
AlphaFold DB A0A155E9Y3

References