Detailed information of TA system TA026392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 2444..2978
• Replicon: plasmid pCD
• Accession: NC_017263
• Organism: Yersinia pestis biovar Medievalis str. Harbin 35

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q663N8
• Locus tag: YPC_RS21000
• Protein ID: WP_002213360.1
• Coordinates: 2444..2743 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9ZGW3
• Locus tag: YPC_RS21005
• Protein ID: WP_002224342.1
• Coordinates: 2736..2978 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPC_RS20985	352..996	+	645	Protein_1	IS3 family transposase	-
YPC_RS20990	1059..1451	-	393	WP_002213403.1	type III secretion system chaperone SycE/YerA	-
YPC_RS20995	1645..2304	+	660	WP_002229754.1	type III secretion system effector GTPase activator YopE	-
YPC_RS21000	2444..2743	-	300	WP_002213360.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YPC_RS21005	2736..2978	-	243	WP_002224342.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
YPC_RS24010	3144..3436	-	293	Protein_6	IS6 family transposase	-
YPC_RS24845	3522..3695	+	174	WP_002213357.1	hypothetical protein	-
YPC_RS24455	3844..4080	-	237	WP_154020274.1	hypothetical protein	-
YPC_RS21015	4240..5205	-	966	WP_002213354.1	ParB/RepB/Spo0J family plasmid partition protein	-
YPC_RS21020	5202..6368	-	1167	WP_002220902.1	plasmid-partitioning protein SopA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	sycE/yerA / yopE / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP / yopO/ypkA / yopO/ypkA / yadA / yadA / sycH	1..68552	68552
	-	flank	IS/Tn	-	-	511..996	485

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Antitoxin ParD (5-72)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11632.19 Da
• Isoelectric Point: 5.5114

>T26392 WP_002213360.1 NC_017263:c2743-2444 [Yersinia pestis biovar Medievalis str. Harbin 35]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Nucleotide

• Length: 300 bp

>T26392 NC_017263:c2743-2444 [Yersinia pestis biovar Medievalis str. Harbin 35]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8865.15 Da
• Isoelectric Point: 6.4781

>AT26392 WP_002224342.1 NC_017263:c2978-2736 [Yersinia pestis biovar Medievalis str. Harbin 35]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV

Nucleotide

• Length: 243 bp

>AT26392 NC_017263:c2978-2736 [Yersinia pestis biovar Medievalis str. Harbin 35]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Structures

Toxin

• AlphaFold DB: Q663N8

Antitoxin

• AlphaFold DB: A0A0E1NQY6