Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 45689..46350 Replicon chromosome
Accession NZ_CP110532
Organism Enterobacter roggenkampii strain ws6-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OM095_RS00230 Protein ID WP_023293716.1
Coordinates 45952..46350 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A156KC23
Locus tag OM095_RS00225 Protein ID WP_032675702.1
Coordinates 45689..45955 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM095_RS00200 (OM095_00200) 41742..43070 - 1329 WP_023326395.1 PTS sugar transporter subunit IIC -
OM095_RS00205 (OM095_00205) 43082..43396 - 315 WP_008500132.1 PTS sugar transporter subunit IIB -
OM095_RS00210 (OM095_00210) 43690..44640 + 951 WP_023293714.1 LacI family DNA-binding transcriptional regulator -
OM095_RS00215 (OM095_00215) 44702..44998 - 297 WP_059365122.1 YicS family protein -
OM095_RS00220 (OM095_00220) 45140..45559 + 420 WP_008500129.1 GNAT family N-acetyltransferase -
OM095_RS00225 (OM095_00225) 45689..45955 + 267 WP_032675702.1 virulence protein Antitoxin
OM095_RS00230 (OM095_00230) 45952..46350 + 399 WP_023293716.1 type II toxin-antitoxin system VapC family toxin Toxin
OM095_RS00235 (OM095_00235) 46490..47290 + 801 WP_008500128.1 lipoprotein NlpA -
OM095_RS00240 (OM095_00240) 47413..48192 + 780 WP_095428878.1 MBL fold metallo-hydrolase -
OM095_RS00245 (OM095_00245) 48219..49172 + 954 WP_044597401.1 helix-turn-helix domain-containing protein -
OM095_RS00250 (OM095_00250) 49355..51052 + 1698 WP_277715335.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14799.00 Da        Isoelectric Point: 6.4779

>T263919 WP_023293716.1 NZ_CP110532:45952-46350 [Enterobacter roggenkampii]
MRHMLDTNIVSHLFKRHPEVVSRMTCLAPGDVCISSITEAELLYGADKKKSSRLKETIREFLNTITICDWDSDAAATYGE
LRATLEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFRMVQELAVEDWTTTL

Download         Length: 399 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10009.34 Da        Isoelectric Point: 4.6310

>AT263919 WP_032675702.1 NZ_CP110532:45689-45955 [Enterobacter roggenkampii]
MERTAKLFRKGQNQAVMLPAEFAFDTESVYIRRDEEGNVVLAAKPVLIKSWDNFLRMLAETDVPDTFLSKEERNQSVTTR
DPLDGACS

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A156KC23

References