Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 19989..20632 Replicon plasmid pRWS292.s3
Accession NZ_CP110526
Organism Klebsiella pneumoniae strain WS_29-2

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OM422_RS28680 Protein ID WP_001044770.1
Coordinates 20216..20632 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OM422_RS28675 Protein ID WP_001261282.1
Coordinates 19989..20219 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM422_RS28655 (OM422_28635) 16054..17427 + 1374 WP_004206605.1 hypothetical protein -
OM422_RS28660 (OM422_28640) 17612..18940 + 1329 WP_004206607.1 nucleotidyltransferase -
OM422_RS28665 (OM422_28645) 18948..19523 + 576 WP_004206608.1 SLATT domain-containing protein -
OM422_RS28670 (OM422_28650) 19790..20032 - 243 Protein_17 hypothetical protein -
OM422_RS28675 (OM422_28655) 19989..20219 + 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OM422_RS28680 (OM422_28660) 20216..20632 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OM422_RS28685 (OM422_28665) 20706..22268 + 1563 WP_004206609.1 AAA family ATPase -
OM422_RS28690 (OM422_28670) 22253..23275 + 1023 WP_000361404.1 helicase UvrD -
OM422_RS28695 (OM422_28675) 23819..24727 + 909 WP_032426221.1 HNH endonuclease -
OM422_RS28700 (OM422_28680) 24913..25263 - 351 WP_004187110.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..213187 213187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T263915 WP_001044770.1 NZ_CP110526:20216-20632 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT263915 WP_001261282.1 NZ_CP110526:19989-20219 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References