Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 234739..235261 Replicon plasmid pRWS292.s1
Accession NZ_CP110524
Organism Klebsiella pneumoniae strain WS_29-2

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag OM422_RS26655 Protein ID WP_004181778.1
Coordinates 234977..235261 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag OM422_RS26650 Protein ID WP_004181777.1
Coordinates 234739..234987 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM422_RS26630 (OM422_26615) 229948..230769 - 822 WP_004181772.1 hypothetical protein -
OM422_RS26635 (OM422_26620) 230831..231184 - 354 WP_004181774.1 hypothetical protein -
OM422_RS26640 (OM422_26625) 231329..232315 - 987 WP_040120328.1 hypothetical protein -
OM422_RS26645 (OM422_26630) 232649..234448 - 1800 WP_038991636.1 ATP-dependent helicase -
OM422_RS26650 (OM422_26635) 234739..234987 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OM422_RS26655 (OM422_26640) 234977..235261 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM422_RS26660 (OM422_26645) 235278..235379 - 102 Protein_263 IS200/IS605 family transposase -
OM422_RS26665 (OM422_26650) 235415..236638 + 1224 WP_004181779.1 RNA-guided endonuclease TnpB family protein -
OM422_RS26670 (OM422_26655) 237029..238216 - 1188 WP_277696569.1 RNA-guided endonuclease TnpB family protein -
OM422_RS26675 (OM422_26660) 238882..239349 + 468 WP_124737156.1 hypothetical protein -
OM422_RS26680 (OM422_26665) 239394..239600 - 207 WP_063938351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..361091 361091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T263913 WP_004181778.1 NZ_CP110524:234977-235261 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT263913 WP_004181777.1 NZ_CP110524:234739-234987 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References