Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 207738..208489 Replicon plasmid pRWS292.s1
Accession NZ_CP110524
Organism Klebsiella pneumoniae strain WS_29-2

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag OM422_RS26495 Protein ID WP_016946197.1
Coordinates 207738..208220 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag OM422_RS26500 Protein ID WP_004902250.1
Coordinates 208211..208489 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM422_RS26475 (OM422_26460) 203281..203607 - 327 Protein_226 IS1 family transposase -
OM422_RS26480 (OM422_26465) 203641..204246 - 606 WP_000509966.1 recombinase family protein -
OM422_RS26485 (OM422_26470) 204341..207238 + 2898 WP_001553819.1 Tn3-like element Tn5403 family transposase -
OM422_RS26490 (OM422_26475) 207274..207647 - 374 Protein_229 IS1 family transposase -
OM422_RS26495 (OM422_26480) 207738..208220 - 483 WP_016946197.1 GNAT family N-acetyltransferase Toxin
OM422_RS26500 (OM422_26485) 208211..208489 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
OM422_RS26505 (OM422_26490) 208611..208823 - 213 WP_016946198.1 hypothetical protein -
OM422_RS26510 (OM422_26495) 208931..209272 - 342 WP_032437747.1 hypothetical protein -
OM422_RS26515 (OM422_26500) 210179..210493 + 315 WP_065800137.1 hypothetical protein -
OM422_RS26520 (OM422_26505) 210737..211219 - 483 WP_169510637.1 hypothetical protein -
OM422_RS26525 (OM422_26510) 212447..213331 + 885 WP_004186900.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..361091 361091
- inside IScluster/Tn - - 187012..207647 20635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17724.53 Da        Isoelectric Point: 8.9130

>T263912 WP_016946197.1 NZ_CP110524:c208220-207738 [Klebsiella pneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWSGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT263912 WP_004902250.1 NZ_CP110524:c208489-208211 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References