263911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 189809..190331 Replicon plasmid pRWS292.s1
Accession NZ_CP110524
Organism Klebsiella pneumoniae strain WS_29-2

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag OM422_RS26400 Protein ID WP_004187019.1
Coordinates 190047..190331 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag OM422_RS26395 Protein ID WP_004187025.1
Coordinates 189809..190057 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM422_RS26375 (OM422_26360) 184832..185806 + 975 WP_003032095.1 SIS domain-containing protein -
OM422_RS26380 (OM422_26365) 185819..186631 + 813 WP_040120122.1 PfkB family carbohydrate kinase -
OM422_RS26385 (OM422_26370) 187012..188037 + 1026 WP_001101446.1 IS110 family transposase -
OM422_RS26390 (OM422_26375) 188332..189300 + 969 WP_000654811.1 IS5 family transposase -
OM422_RS26395 (OM422_26380) 189809..190057 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
OM422_RS26400 (OM422_26385) 190047..190331 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM422_RS26405 (OM422_26390) 190347..191645 - 1299 WP_277696568.1 ISNCY family transposase -
OM422_RS26410 (OM422_26395) 191679..192647 - 969 WP_000654811.1 IS5 family transposase -
OM422_RS26415 (OM422_26400) 192844..194376 + 1533 WP_009310015.1 IS3-like element ISKpn38 family transposase -
OM422_RS26420 (OM422_26405) 194643..195071 - 429 WP_277696550.1 glutaredoxin-dependent arsenate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..361091 361091
- inside IScluster/Tn - - 187012..207647 20635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T263911 WP_004187019.1 NZ_CP110524:190047-190331 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT263911 WP_004187025.1 NZ_CP110524:189809-190057 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References