Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 159342..160252 | Replicon | plasmid pRWS292.s1 |
| Accession | NZ_CP110524 | ||
| Organism | Klebsiella pneumoniae strain WS_29-2 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A1D8K2L2 |
| Locus tag | OM422_RS26225 | Protein ID | WP_070083042.1 |
| Coordinates | 159342..159812 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A7H4PRG4 |
| Locus tag | OM422_RS26230 | Protein ID | WP_032413443.1 |
| Coordinates | 159809..160252 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OM422_RS26205 (OM422_26190) | 155481..156449 | + | 969 | WP_000654804.1 | IS5-like element IS903B family transposase | - |
| OM422_RS26210 (OM422_26195) | 156508..156906 | + | 399 | Protein_173 | integrase core domain-containing protein | - |
| OM422_RS26220 (OM422_26205) | 158972..159232 | + | 261 | WP_017901409.1 | hypothetical protein | - |
| OM422_RS26225 (OM422_26210) | 159342..159812 | - | 471 | WP_070083042.1 | RES family NAD+ phosphorylase | Toxin |
| OM422_RS26230 (OM422_26215) | 159809..160252 | - | 444 | WP_032413443.1 | DUF2384 domain-containing protein | Antitoxin |
| OM422_RS26235 (OM422_26220) | 160352..160549 | - | 198 | Protein_178 | DUF4113 domain-containing protein | - |
| OM422_RS26240 (OM422_26225) | 160591..161559 | - | 969 | WP_000654804.1 | IS5-like element IS903B family transposase | - |
| OM422_RS26245 (OM422_26230) | 161854..162879 | - | 1026 | WP_001101446.1 | IS110 family transposase | - |
| OM422_RS26250 (OM422_26235) | 162924..163793 | + | 870 | WP_277696547.1 | GGDEF domain-containing protein | - |
| OM422_RS26255 (OM422_26240) | 163885..164112 | - | 228 | Protein_182 | IS3 family transposase | - |
| OM422_RS26260 (OM422_26245) | 164123..164292 | + | 170 | Protein_183 | LysR family transcriptional regulator | - |
| OM422_RS26265 (OM422_26250) | 164419..164532 | - | 114 | Protein_184 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..361091 | 361091 | |
| - | inside | IScluster/Tn | - | - | 142777..181663 | 38886 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17587.85 Da Isoelectric Point: 4.5244
>T263910 WP_070083042.1 NZ_CP110524:c159812-159342 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMESFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMESFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16508.82 Da Isoelectric Point: 10.3013
>AT263910 WP_032413443.1 NZ_CP110524:c160252-159809 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1D8K2L2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7H4PRG4 |