Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 36464..37374 | Replicon | plasmid pRWS292.s1 |
| Accession | NZ_CP110524 | ||
| Organism | Klebsiella pneumoniae strain WS_29-2 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A1D8K2L2 |
| Locus tag | OM422_RS25585 | Protein ID | WP_070083042.1 |
| Coordinates | 36904..37374 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | OM422_RS25580 | Protein ID | WP_004181895.1 |
| Coordinates | 36464..36907 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OM422_RS25555 (OM422_25540) | 31620..31835 | - | 216 | Protein_42 | IS200/IS605 family transposase | - |
| OM422_RS25560 (OM422_25545) | 31837..32406 | + | 570 | Protein_43 | transposase | - |
| OM422_RS25565 (OM422_25550) | 32774..34261 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| OM422_RS25570 (OM422_25555) | 34670..35092 | + | 423 | WP_135717959.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| OM422_RS25575 (OM422_25560) | 35092..36363 | + | 1272 | WP_004197886.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| OM422_RS25580 (OM422_25565) | 36464..36907 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| OM422_RS25585 (OM422_25570) | 36904..37374 | + | 471 | WP_070083042.1 | RES family NAD+ phosphorylase | Toxin |
| OM422_RS25590 (OM422_25575) | 37485..37745 | - | 261 | WP_070083041.1 | hypothetical protein | - |
| OM422_RS25595 (OM422_25580) | 38435..39804 | + | 1370 | WP_085956500.1 | IS3-like element ISKpn8 family transposase | - |
| OM422_RS25600 (OM422_25585) | 39982..41322 | + | 1341 | WP_000589001.1 | ISNCY family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..361091 | 361091 | |
| - | flank | IS/Tn | - | - | 32020..32406 | 386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17587.85 Da Isoelectric Point: 4.5244
>T263906 WP_070083042.1 NZ_CP110524:36904-37374 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMESFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMESFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT263906 WP_004181895.1 NZ_CP110524:36464-36907 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1D8K2L2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |