Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5108205..5108830 Replicon chromosome
Accession NZ_CP110523
Organism Klebsiella pneumoniae strain WS_29-2

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OM422_RS24980 Protein ID WP_002882817.1
Coordinates 5108205..5108588 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OM422_RS24985 Protein ID WP_004150355.1
Coordinates 5108588..5108830 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM422_RS24965 (5105571) 5105571..5106473 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OM422_RS24970 (5106470) 5106470..5107105 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OM422_RS24975 (5107102) 5107102..5108031 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OM422_RS24980 (5108205) 5108205..5108588 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OM422_RS24985 (5108588) 5108588..5108830 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OM422_RS24990 (5109035) 5109035..5109952 + 918 WP_032422045.1 alpha/beta hydrolase -
OM422_RS24995 (5109966) 5109966..5110907 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OM422_RS25000 (5110952) 5110952..5111389 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OM422_RS25005 (5111386) 5111386..5112246 - 861 WP_004146232.1 virulence factor BrkB family protein -
OM422_RS25010 (5112240) 5112240..5112839 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T263905 WP_002882817.1 NZ_CP110523:c5108588-5108205 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263905 WP_004150355.1 NZ_CP110523:c5108830-5108588 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References