Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4593782..4594298 Replicon chromosome
Accession NZ_CP110523
Organism Klebsiella pneumoniae strain WS_29-2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OM422_RS22505 Protein ID WP_004178374.1
Coordinates 4593782..4594066 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OM422_RS22510 Protein ID WP_002886901.1
Coordinates 4594056..4594298 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM422_RS22480 (4589198) 4589198..4589461 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
OM422_RS22485 (4589591) 4589591..4589764 + 174 WP_002886906.1 hypothetical protein -
OM422_RS22490 (4589767) 4589767..4590510 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OM422_RS22495 (4590867) 4590867..4593005 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OM422_RS22500 (4593314) 4593314..4593778 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OM422_RS22505 (4593782) 4593782..4594066 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM422_RS22510 (4594056) 4594056..4594298 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OM422_RS22515 (4594376) 4594376..4596286 - 1911 WP_032421964.1 PRD domain-containing protein -
OM422_RS22520 (4596309) 4596309..4597463 - 1155 WP_032421963.1 lactonase family protein -
OM422_RS22525 (4597530) 4597530..4598270 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T263903 WP_004178374.1 NZ_CP110523:c4594066-4593782 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT263903 WP_002886901.1 NZ_CP110523:c4594298-4594056 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References