Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 234824..235346 Replicon plasmid pRWS291.s1
Accession NZ_CP110515
Organism Klebsiella pneumoniae strain WS_29-1

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag OM421_RS26690 Protein ID WP_004181778.1
Coordinates 235062..235346 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag OM421_RS26685 Protein ID WP_004181777.1
Coordinates 234824..235072 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM421_RS26665 (OM421_26655) 230033..230854 - 822 WP_004181772.1 hypothetical protein -
OM421_RS26670 (OM421_26660) 230916..231269 - 354 WP_004181774.1 hypothetical protein -
OM421_RS26675 (OM421_26665) 231414..232400 - 987 WP_040120328.1 hypothetical protein -
OM421_RS26680 (OM421_26670) 232734..234533 - 1800 WP_038991636.1 ATP-dependent helicase -
OM421_RS26685 (OM421_26675) 234824..235072 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OM421_RS26690 (OM421_26680) 235062..235346 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM421_RS26695 (OM421_26685) 235363..235464 - 102 Protein_263 IS200/IS605 family transposase -
OM421_RS26700 (OM421_26690) 235500..236723 + 1224 WP_004181779.1 RNA-guided endonuclease TnpB family protein -
OM421_RS26705 (OM421_26695) 237114..238301 - 1188 WP_277696569.1 RNA-guided endonuclease TnpB family protein -
OM421_RS26710 (OM421_26700) 238967..239434 + 468 WP_124737156.1 hypothetical protein -
OM421_RS26715 (OM421_26705) 239479..239685 - 207 WP_063938351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..361178 361178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T263886 WP_004181778.1 NZ_CP110515:235062-235346 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT263886 WP_004181777.1 NZ_CP110515:234824-235072 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References