Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 189809..190331 Replicon plasmid pRWS291.s1
Accession NZ_CP110515
Organism Klebsiella pneumoniae strain WS_29-1

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag OM421_RS26430 Protein ID WP_004187019.1
Coordinates 190047..190331 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag OM421_RS26425 Protein ID WP_004187025.1
Coordinates 189809..190057 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM421_RS26405 (OM421_26395) 184832..185806 + 975 WP_003032095.1 SIS domain-containing protein -
OM421_RS26410 (OM421_26400) 185819..186631 + 813 WP_040120122.1 PfkB family carbohydrate kinase -
OM421_RS26415 (OM421_26405) 187012..188037 + 1026 WP_001101446.1 IS110 family transposase -
OM421_RS26420 (OM421_26410) 188332..189300 + 969 WP_000654811.1 IS5 family transposase -
OM421_RS26425 (OM421_26415) 189809..190057 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
OM421_RS26430 (OM421_26420) 190047..190331 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM421_RS26435 (OM421_26425) 190347..191645 - 1299 WP_277696568.1 ISNCY family transposase -
OM421_RS26440 (OM421_26430) 191679..192647 - 969 WP_000654811.1 IS5 family transposase -
OM421_RS26445 (OM421_26435) 192844..194376 + 1533 WP_009310015.1 IS3-like element ISKpn38 family transposase -
OM421_RS26450 (OM421_26440) 194643..195071 - 429 WP_277696550.1 glutaredoxin-dependent arsenate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..361178 361178
- inside IScluster/Tn - - 187012..207647 20635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T263884 WP_004187019.1 NZ_CP110515:190047-190331 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT263884 WP_004187025.1 NZ_CP110515:189809-190057 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References