Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5112148..5112773 Replicon chromosome
Accession NZ_CP110514
Organism Klebsiella pneumoniae strain WS_29-1

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OM421_RS25015 Protein ID WP_002882817.1
Coordinates 5112148..5112531 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OM421_RS25020 Protein ID WP_004150355.1
Coordinates 5112531..5112773 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM421_RS25000 (5109514) 5109514..5110416 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OM421_RS25005 (5110413) 5110413..5111048 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OM421_RS25010 (5111045) 5111045..5111974 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OM421_RS25015 (5112148) 5112148..5112531 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OM421_RS25020 (5112531) 5112531..5112773 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OM421_RS25025 (5112978) 5112978..5113895 + 918 WP_032422045.1 alpha/beta hydrolase -
OM421_RS25030 (5113909) 5113909..5114850 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OM421_RS25035 (5114895) 5114895..5115332 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OM421_RS25040 (5115329) 5115329..5116189 - 861 WP_004146232.1 virulence factor BrkB family protein -
OM421_RS25045 (5116183) 5116183..5116782 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T263878 WP_002882817.1 NZ_CP110514:c5112531-5112148 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263878 WP_004150355.1 NZ_CP110514:c5112773-5112531 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References