Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4757082..4758763 Replicon chromosome
Accession NZ_CP110514
Organism Klebsiella pneumoniae strain WS_29-1

Toxin (Protein)


Gene name mosT Uniprot ID A0A2L0KL13
Locus tag OM421_RS23335 Protein ID WP_019704723.1
Coordinates 4757082..4757999 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OM421_RS23340 Protein ID WP_004177809.1
Coordinates 4758005..4758763 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM421_RS23315 (4752388) 4752388..4753908 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
OM421_RS23320 (4753905) 4753905..4754903 + 999 WP_277696434.1 ribose ABC transporter permease -
OM421_RS23325 (4754934) 4754934..4755875 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OM421_RS23330 (4755950) 4755950..4756957 + 1008 WP_009484222.1 carbohydrate kinase family protein -
OM421_RS23335 (4757082) 4757082..4757999 - 918 WP_019704723.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OM421_RS23340 (4758005) 4758005..4758763 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OM421_RS23345 (4758849) 4758849..4759577 - 729 WP_004177810.1 response regulator transcription factor -
OM421_RS23350 (4759850) 4759850..4761997 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
OM421_RS23355 (4762227) 4762227..4762913 + 687 WP_032421940.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34632.07 Da        Isoelectric Point: 5.4707

>T263877 WP_019704723.1 NZ_CP110514:c4757999-4757082 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT263877 WP_004177809.1 NZ_CP110514:c4758763-4758005 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0KL13

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References