Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4595827..4596343 Replicon chromosome
Accession NZ_CP110514
Organism Klebsiella pneumoniae strain WS_29-1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OM421_RS22530 Protein ID WP_004178374.1
Coordinates 4595827..4596111 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OM421_RS22535 Protein ID WP_002886901.1
Coordinates 4596101..4596343 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM421_RS22505 (4591243) 4591243..4591506 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
OM421_RS22510 (4591636) 4591636..4591809 + 174 WP_002886906.1 hypothetical protein -
OM421_RS22515 (4591812) 4591812..4592555 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OM421_RS22520 (4592912) 4592912..4595050 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OM421_RS22525 (4595359) 4595359..4595823 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OM421_RS22530 (4595827) 4595827..4596111 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM421_RS22535 (4596101) 4596101..4596343 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OM421_RS22540 (4596421) 4596421..4598331 - 1911 WP_032421964.1 PRD domain-containing protein -
OM421_RS22545 (4598354) 4598354..4599508 - 1155 WP_032421963.1 lactonase family protein -
OM421_RS22550 (4599575) 4599575..4600315 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T263876 WP_004178374.1 NZ_CP110514:c4596111-4595827 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT263876 WP_002886901.1 NZ_CP110514:c4596343-4596101 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References