Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2549769..2551357 Replicon chromosome
Accession NZ_CP110514
Organism Klebsiella pneumoniae strain WS_29-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag OM421_RS12595 Protein ID WP_023301940.1
Coordinates 2549769..2551091 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OM421_RS12600 Protein ID WP_002904790.1
Coordinates 2551091..2551357 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM421_RS12580 (2544825) 2544825..2547326 + 2502 WP_038435307.1 fimbria/pilus outer membrane usher protein -
OM421_RS12585 (2547314) 2547314..2548318 + 1005 WP_032421320.1 fimbrial protein -
OM421_RS12590 (2548460) 2548460..2549752 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OM421_RS12595 (2549769) 2549769..2551091 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
OM421_RS12600 (2551091) 2551091..2551357 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OM421_RS12605 (2551744) 2551744..2552070 - 327 WP_004215084.1 hydroxyisourate hydrolase -
OM421_RS12610 (2552067) 2552067..2552567 - 501 WP_023282573.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OM421_RS12615 (2552545) 2552545..2553924 - 1380 WP_032421319.1 nucleobase:cation symporter-2 family protein -
OM421_RS12620 (2554270) 2554270..2555424 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OM421_RS12625 (2555405) 2555405..2556328 - 924 WP_032421318.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T263873 WP_023301940.1 NZ_CP110514:c2551091-2549769 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT263873 WP_002904790.1 NZ_CP110514:c2551357-2551091 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References