Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 817550..818207 Replicon chromosome
Accession NZ_CP110514
Organism Klebsiella pneumoniae strain WS_29-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OM421_RS04120 Protein ID WP_002916310.1
Coordinates 817797..818207 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OM421_RS04115 Protein ID WP_002916312.1
Coordinates 817550..817816 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM421_RS04090 (812706) 812706..814139 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OM421_RS04095 (814258) 814258..814986 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OM421_RS04100 (815036) 815036..815347 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OM421_RS04105 (815511) 815511..816170 + 660 WP_002916317.1 hemolysin III family protein -
OM421_RS04110 (816321) 816321..817304 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OM421_RS04115 (817550) 817550..817816 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OM421_RS04120 (817797) 817797..818207 + 411 WP_002916310.1 protein YgfX Toxin
OM421_RS04125 (818214) 818214..818735 - 522 WP_002916308.1 flavodoxin FldB -
OM421_RS04130 (818836) 818836..819732 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OM421_RS04135 (819755) 819755..820468 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OM421_RS04140 (820474) 820474..822207 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T263868 WP_002916310.1 NZ_CP110514:817797-818207 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT263868 WP_002916312.1 NZ_CP110514:817550-817816 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References