Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1988..2535 Replicon plasmid pRWS532
Accession NZ_CP110513
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag OM087_RS23845 Protein ID WP_001384452.1
Coordinates 2257..2535 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID F4V9S6
Locus tag OM087_RS23840 Protein ID WP_000079931.1
Coordinates 1988..2257 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS23835 (46) 46..1077 + 1032 WP_000907868.1 plasmid replication initiator RepA -
OM087_RS23840 (1988) 1988..2257 + 270 WP_000079931.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
OM087_RS23845 (2257) 2257..2535 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
OM087_RS23850 (2731) 2731..3027 - 297 WP_001419651.1 hypothetical protein -
OM087_RS23855 (3372) 3372..3959 + 588 WP_032274974.1 serine acetyltransferase -
OM087_RS23860 (4241) 4241..4834 - 594 WP_069200664.1 ProQ/FINO family protein -
OM087_RS23865 (5056) 5056..5331 - 276 WP_072034596.1 hypothetical protein -
OM087_RS23870 (5435) 5435..6025 - 591 WP_047649953.1 hypothetical protein -
OM087_RS23875 (6025) 6025..6282 - 258 WP_000343085.1 hypothetical protein -
OM087_RS23880 (6852) 6852..7166 + 315 WP_001302628.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..83623 83623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T263860 WP_001384452.1 NZ_CP110513:2257-2535 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10194.55 Da        Isoelectric Point: 8.8735

>AT263860 WP_000079931.1 NZ_CP110513:1988-2257 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DLR5

References