Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 71627..72162 Replicon plasmid pRWS531
Accession NZ_CP110512
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag OM087_RS23580 Protein ID WP_000222771.1
Coordinates 71875..72162 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag OM087_RS23575 Protein ID WP_001139206.1
Coordinates 71627..71878 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS23570 (OM087_23480) 67076..71044 - 3969 Protein_78 helicase-related protein -
OM087_RS23575 (OM087_23485) 71627..71878 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OM087_RS23580 (OM087_23490) 71875..72162 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM087_RS23585 (OM087_23495) 72530..72643 - 114 Protein_81 alkaline phosphatase -
OM087_RS23590 (OM087_23500) 72642..72847 + 206 Protein_82 hypothetical protein -
OM087_RS23595 (OM087_23505) 73022..76519 - 3498 WP_247192720.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) / qnrS1 / dfrA14 / dfrA12 / aadA2 / qacE / sul1 / blaNDM-5 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / floR - 1..118422 118422
- flank IS/Tn - - 77038..77292 254


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T263859 WP_000222771.1 NZ_CP110512:71875-72162 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT263859 WP_001139206.1 NZ_CP110512:71627-71878 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References