Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4358292..4358917 Replicon chromosome
Accession NZ_CP110511
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag OM087_RS20950 Protein ID WP_000911329.1
Coordinates 4358519..4358917 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag OM087_RS20945 Protein ID WP_000450524.1
Coordinates 4358292..4358519 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS20920 (4354094) 4354094..4354564 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
OM087_RS20925 (4354564) 4354564..4355136 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
OM087_RS20930 (4355282) 4355282..4356160 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
OM087_RS20935 (4356177) 4356177..4357211 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
OM087_RS20940 (4357424) 4357424..4358137 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
OM087_RS20945 (4358292) 4358292..4358519 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
OM087_RS20950 (4358519) 4358519..4358917 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
OM087_RS20955 (4359064) 4359064..4359927 + 864 WP_001267498.1 neutral zinc metallopeptidase -
OM087_RS20960 (4359942) 4359942..4361957 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
OM087_RS20965 (4362031) 4362031..4362729 + 699 WP_000679812.1 esterase -
OM087_RS20970 (4362810) 4362810..4363010 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T263857 WP_000911329.1 NZ_CP110511:4358519-4358917 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT263857 WP_000450524.1 NZ_CP110511:4358292-4358519 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References