Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3927567..3928221 Replicon chromosome
Accession NZ_CP110511
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag OM087_RS18925 Protein ID WP_000244781.1
Coordinates 3927814..3928221 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OM087_RS18920 Protein ID WP_000354046.1
Coordinates 3927567..3927833 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS18895 (3922850) 3922850..3923593 + 744 WP_115724079.1 SDR family oxidoreductase -
OM087_RS18900 (3923655) 3923655..3925088 - 1434 WP_162822830.1 6-phospho-beta-glucosidase BglA -
OM087_RS18905 (3925133) 3925133..3925444 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
OM087_RS18910 (3925608) 3925608..3926267 + 660 WP_000250274.1 hemolysin III family protein -
OM087_RS18915 (3926344) 3926344..3927324 - 981 WP_000886074.1 tRNA-modifying protein YgfZ -
OM087_RS18920 (3927567) 3927567..3927833 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OM087_RS18925 (3927814) 3927814..3928221 + 408 WP_000244781.1 protein YgfX Toxin
OM087_RS18930 (3928261) 3928261..3928782 - 522 WP_001055874.1 flavodoxin FldB -
OM087_RS18935 (3928894) 3928894..3929790 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OM087_RS18940 (3929815) 3929815..3930525 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OM087_RS18945 (3930531) 3930531..3932264 + 1734 WP_115724081.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T263855 WP_000244781.1 NZ_CP110511:3927814-3928221 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT263855 WP_000354046.1 NZ_CP110511:3927567-3927833 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References