Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3309760..3310391 Replicon chromosome
Accession NZ_CP110511
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag OM087_RS15785 Protein ID WP_001259385.1
Coordinates 3309760..3310035 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag OM087_RS15790 Protein ID WP_000593555.1
Coordinates 3310032..3310391 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS15770 (3304778) 3304778..3305845 + 1068 WP_000361485.1 HlyD family secretion protein -
OM087_RS15775 (3305842) 3305842..3308577 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
OM087_RS15780 (3308577) 3308577..3309701 + 1125 WP_001314210.1 ABC transporter permease -
OM087_RS15785 (3309760) 3309760..3310035 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
OM087_RS15790 (3310032) 3310032..3310391 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OM087_RS15795 (3310441) 3310441..3311301 - 861 WP_001131788.1 class II aldolase -
OM087_RS15800 (3311333) 3311333..3311602 - 270 WP_096266505.1 HPr family phosphocarrier protein -
OM087_RS15805 (3311592) 3311592..3313100 - 1509 WP_115724130.1 FGGY-family carbohydrate kinase -
OM087_RS15810 (3313093) 3313093..3314451 - 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
OM087_RS15815 (3314528) 3314528..3314809 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
OM087_RS15820 (3314806) 3314806..3315279 - 474 WP_001161650.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3302790..3316050 13260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T263852 WP_001259385.1 NZ_CP110511:3309760-3310035 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT263852 WP_000593555.1 NZ_CP110511:3310032-3310391 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References