Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2571597..2572094 Replicon chromosome
Accession NZ_CP110511
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OM087_RS12355 Protein ID WP_001173343.1
Coordinates 2571597..2571770 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag OM087_RS12360 Protein ID WP_001425728.1
Coordinates 2571798..2572094 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS12345 (2568267) 2568267..2569724 + 1458 WP_115724168.1 dipeptide/tripeptide permease DtpC -
OM087_RS12350 (2569961) 2569961..2571478 + 1518 WP_001295074.1 lysine--tRNA ligase -
OM087_RS12355 (2571597) 2571597..2571770 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OM087_RS12360 (2571798) 2571798..2572094 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OM087_RS12365 (2572321) 2572321..2572593 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
OM087_RS12370 (2572605) 2572605..2572835 - 231 WP_016241784.1 4Fe-4S mono-cluster protein YjdI -
OM087_RS12375 (2573016) 2573016..2574647 + 1632 WP_001216477.1 sensor histidine kinase -
OM087_RS12380 (2574644) 2574644..2575363 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T263850 WP_001173343.1 NZ_CP110511:c2571770-2571597 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT263850 WP_001425728.1 NZ_CP110511:c2572094-2571798 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References