263846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1787197..1788034 Replicon chromosome
Accession NZ_CP110511
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag OM087_RS08640 Protein ID WP_000227784.1
Coordinates 1787492..1788034 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag OM087_RS08635 Protein ID WP_001297137.1
Coordinates 1787197..1787508 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS08610 (1782217) 1782217..1783164 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
OM087_RS08615 (1783186) 1783186..1785177 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
OM087_RS08620 (1785167) 1785167..1785781 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
OM087_RS08625 (1785781) 1785781..1786110 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
OM087_RS08630 (1786122) 1786122..1787012 + 891 WP_000971336.1 heme o synthase -
OM087_RS08635 (1787197) 1787197..1787508 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
OM087_RS08640 (1787492) 1787492..1788034 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
OM087_RS08645 (1788090) 1788090..1789025 - 936 WP_001297127.1 tetratricopeptide repeat protein -
OM087_RS08650 (1789433) 1789433..1790797 + 1365 WP_001000978.1 MFS transporter -
OM087_RS08655 (1790925) 1790925..1791416 - 492 WP_001138904.1 nucleotide binding protein YajQ -
OM087_RS08660 (1791584) 1791584..1792495 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T263846 WP_000227784.1 NZ_CP110511:1787492-1788034 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT263846 WP_001297137.1 NZ_CP110511:1787197-1787508 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References