Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1753108..1753726 Replicon chromosome
Accession NZ_CP110511
Organism Escherichia coli strain ws5-3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OM087_RS08470 Protein ID WP_001291435.1
Coordinates 1753508..1753726 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OM087_RS08465 Protein ID WP_000344800.1
Coordinates 1753108..1753482 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM087_RS08455 (1748197) 1748197..1749390 + 1194 WP_277716277.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OM087_RS08460 (1749413) 1749413..1752562 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OM087_RS08465 (1753108) 1753108..1753482 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OM087_RS08470 (1753508) 1753508..1753726 + 219 WP_001291435.1 HHA domain-containing protein Toxin
OM087_RS08475 (1753898) 1753898..1754449 + 552 WP_000102564.1 maltose O-acetyltransferase -
OM087_RS08480 (1754565) 1754565..1755035 + 471 WP_000136192.1 YlaC family protein -
OM087_RS08485 (1755199) 1755199..1756749 + 1551 WP_115724151.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OM087_RS08490 (1756791) 1756791..1757144 - 354 WP_000878140.1 DUF1428 domain-containing protein -
OM087_RS08500 (1757522) 1757522..1757833 + 312 WP_162822834.1 MGMT family protein -
OM087_RS08505 (1757864) 1757864..1758436 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T263845 WP_001291435.1 NZ_CP110511:1753508-1753726 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT263845 WP_000344800.1 NZ_CP110511:1753108-1753482 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References