Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2314476..2315109 Replicon chromosome
Accession NZ_CP110483
Organism Weizmannia coagulans strain XY2

Toxin (Protein)


Gene name mazF Uniprot ID G2TIM0
Locus tag ONG97_RS11625 Protein ID WP_013860680.1
Coordinates 2314759..2315109 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G2TIL9
Locus tag ONG97_RS11620 Protein ID WP_014096808.1
Coordinates 2314476..2314754 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONG97_RS11600 (ONG97_11600) 2310589..2311188 - 600 WP_019720980.1 rhomboid family intramembrane serine protease -
ONG97_RS11605 (ONG97_11605) 2311463..2311813 + 351 WP_133536150.1 holo-ACP synthase -
ONG97_RS11610 (ONG97_11610) 2311954..2312970 + 1017 WP_265114672.1 outer membrane lipoprotein carrier protein LolA -
ONG97_RS11615 (ONG97_11615) 2313172..2314323 + 1152 WP_265114673.1 alanine racemase -
ONG97_RS11620 (ONG97_11620) 2314476..2314754 + 279 WP_014096808.1 hypothetical protein Antitoxin
ONG97_RS11625 (ONG97_11625) 2314759..2315109 + 351 WP_013860680.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ONG97_RS11630 (ONG97_11630) 2315591..2316418 + 828 WP_265114674.1 RsbT co-antagonist protein RsbRA -
ONG97_RS11635 (ONG97_11635) 2316422..2316778 + 357 WP_017553290.1 STAS domain-containing protein -
ONG97_RS11640 (ONG97_11640) 2316783..2317184 + 402 WP_013860676.1 anti-sigma regulatory factor -
ONG97_RS11645 (ONG97_11645) 2317199..2318242 + 1044 Protein_2287 PP2C family protein-serine/threonine phosphatase -
ONG97_RS11650 (ONG97_11650) 2318279..2318608 + 330 WP_013860674.1 anti-sigma factor antagonist -
ONG97_RS11655 (ONG97_11655) 2318612..2319082 + 471 WP_265114675.1 anti-sigma B factor RsbW -
ONG97_RS11660 (ONG97_11660) 2319060..2319839 + 780 WP_265114676.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12968.01 Da        Isoelectric Point: 4.8998

>T263839 WP_013860680.1 NZ_CP110483:2314759-2315109 [Weizmannia coagulans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGLERDSVILLEQI
RTIDKQRLTDKITHLDEEVMEKIDDALQISLGLVEF

Download         Length: 351 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10633.19 Da        Isoelectric Point: 5.2204

>AT263839 WP_014096808.1 NZ_CP110483:2314476-2314754 [Weizmannia coagulans]
VSEPISTEILVRLPQQLLTELDGFAETENMNRNELIYRATKMYLKERKKRQIRETMRRGYMEMAKINLAIASEAIQAEYE
AEHTVESLVSGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4BYJ0

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4BX66

References