Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 475580..476550 | Replicon | plasmid pRho-G13 |
| Accession | NZ_CP110470 | ||
| Organism | Rhodococcus opacus strain G13 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | ONE62_RS40495 | Protein ID | WP_265147867.1 |
| Coordinates | 475960..476550 (+) | Length | 197 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | ONE62_RS40490 | Protein ID | WP_206016785.1 |
| Coordinates | 475580..475963 (+) | Length | 128 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ONE62_RS40465 (ONE62_40455) | 470855..471163 | + | 309 | WP_265147864.1 | hypothetical protein | - |
| ONE62_RS40470 (ONE62_40460) | 471160..471654 | + | 495 | WP_061699536.1 | hypothetical protein | - |
| ONE62_RS40475 (ONE62_40465) | 471651..471968 | + | 318 | WP_065493620.1 | hypothetical protein | - |
| ONE62_RS40480 (ONE62_40470) | 472348..473658 | + | 1311 | WP_265147865.1 | Rep protein | - |
| ONE62_RS40485 (ONE62_40475) | 473916..474920 | + | 1005 | WP_265147866.1 | acyl-CoA dehydrogenase family protein | - |
| ONE62_RS40490 (ONE62_40480) | 475580..475963 | + | 384 | WP_206016785.1 | hypothetical protein | Antitoxin |
| ONE62_RS40495 (ONE62_40485) | 475960..476550 | + | 591 | WP_265147867.1 | zeta toxin family protein | Toxin |
| ONE62_RS40500 (ONE62_40490) | 477471..478778 | + | 1308 | WP_265147868.1 | PucR family transcriptional regulator | - |
| ONE62_RS40505 (ONE62_40495) | 478931..479680 | + | 750 | WP_265147869.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| ONE62_RS40510 (ONE62_40500) | 479955..480425 | + | 471 | WP_265147870.1 | nuclear transport factor 2 family protein | - |
| ONE62_RS40515 (ONE62_40505) | 480491..481336 | + | 846 | WP_265147871.1 | fumarylacetoacetate hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..1100117 | 1100117 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 197 a.a. Molecular weight: 21548.40 Da Isoelectric Point: 7.2777
>T263831 WP_265147867.1 NZ_CP110470:475960-476550 [Rhodococcus opacus]
VKRLDLVAGCNGAGKSTFVAFTLAPLLPASPLVNADEIATQRWPADPAIHSYEAAEIAAKTRAHLLTLGKSFIAATVFSH
PSKLELIDQARTHDYTVVLHVVMIPEELAVQRVRYRAQAGGHEVPEDKIRQRYQRIWSLLAQAFPRSDHVTVYDNSSSTG
PRIVAQFTDGHLVGEATWPAWTPAELTSHTSRGEHP
VKRLDLVAGCNGAGKSTFVAFTLAPLLPASPLVNADEIATQRWPADPAIHSYEAAEIAAKTRAHLLTLGKSFIAATVFSH
PSKLELIDQARTHDYTVVLHVVMIPEELAVQRVRYRAQAGGHEVPEDKIRQRYQRIWSLLAQAFPRSDHVTVYDNSSSTG
PRIVAQFTDGHLVGEATWPAWTPAELTSHTSRGEHP
Download Length: 591 bp
Antitoxin
Download Length: 128 a.a. Molecular weight: 13710.21 Da Isoelectric Point: 4.9627
>AT263831 WP_206016785.1 NZ_CP110470:475580-475963 [Rhodococcus opacus]
MHSTGDKVTRLAADLVASAMAEGERQHRTGRQQLEHWARVGRAVSSRQTAARRRVEDALAGRLPLGELGPEEGTVFNAEI
NAAIEEQLATTDYGSTLAAQGITTVALSEDGQIIEYRPDGTRTILPE
MHSTGDKVTRLAADLVASAMAEGERQHRTGRQQLEHWARVGRAVSSRQTAARRRVEDALAGRLPLGELGPEEGTVFNAEI
NAAIEEQLATTDYGSTLAAQGITTVALSEDGQIIEYRPDGTRTILPE
Download Length: 384 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|