263827

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2905..3493 Replicon plasmid pRBH2-2
Accession NZ_CP110464
Organism Acinetobacter baumannii strain RBH2

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag OMP06_RS19060 Protein ID WP_000438826.1
Coordinates 2905..3192 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag OMP06_RS19065 Protein ID WP_001983304.1
Coordinates 3179..3493 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP06_RS19040 (OMP06_19040) 144..1094 + 951 WP_001208778.1 replication initiation protein RepM -
OMP06_RS19045 (OMP06_19045) 1087..1662 + 576 WP_001096619.1 plasmid replication DNA-binding protein -
OMP06_RS19050 (OMP06_19050) 1682..1825 + 144 WP_001125246.1 hypothetical protein -
OMP06_RS19055 (OMP06_19055) 2014..2532 - 519 WP_000447193.1 tetratricopeptide repeat protein -
OMP06_RS19060 (OMP06_19060) 2905..3192 + 288 WP_000438826.1 BrnT family toxin Toxin
OMP06_RS19065 (OMP06_19065) 3179..3493 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
OMP06_RS19070 (OMP06_19070) 3621..6032 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
OMP06_RS19075 (OMP06_19075) 6337..6798 + 462 WP_000761346.1 DIP1984 family protein -
OMP06_RS19080 (OMP06_19080) 7234..8202 - 969 WP_012308653.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-VIa - 1..12952 12952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T263827 WP_000438826.1 NZ_CP110464:2905-3192 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT263827 WP_001983304.1 NZ_CP110464:3179-3493 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References