Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2067656..2069292 Replicon chromosome
Accession NZ_CP110462
Organism Acinetobacter baumannii strain RBH2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OMP06_RS09915 Protein ID WP_265167538.1
Coordinates 2067961..2069292 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OMP06_RS09910 Protein ID WP_001101310.1
Coordinates 2067656..2067964 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP06_RS09890 (OMP06_09890) 2063970..2064431 + 462 WP_032059820.1 hypothetical protein -
OMP06_RS09895 (OMP06_09895) 2064708..2065103 - 396 WP_265167536.1 hypothetical protein -
OMP06_RS09900 (OMP06_09900) 2065349..2065687 - 339 WP_005075983.1 helix-turn-helix domain-containing protein -
OMP06_RS09905 (OMP06_09905) 2066388..2066936 - 549 WP_265167537.1 TetR/AcrR family transcriptional regulator -
OMP06_RS09910 (OMP06_09910) 2067656..2067964 - 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
OMP06_RS09915 (OMP06_09915) 2067961..2069292 - 1332 WP_265167538.1 HipA domain-containing protein Toxin
OMP06_RS09920 (OMP06_09920) 2069588..2070028 + 441 WP_265167539.1 HD domain-containing protein -
OMP06_RS09925 (OMP06_09925) 2070065..2070709 - 645 WP_223070278.1 hypothetical protein -
OMP06_RS09930 (OMP06_09930) 2070721..2071692 - 972 WP_223070276.1 5'/3'-nucleotidase SurE -
OMP06_RS09935 (OMP06_09935) 2071819..2072982 - 1164 WP_223070275.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51132.24 Da        Isoelectric Point: 4.8519

>T263825 WP_265167538.1 NZ_CP110462:c2069292-2067961 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARLYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPDSTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT263825 WP_001101310.1 NZ_CP110462:c2067964-2067656 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References