Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2159917..2160554 Replicon chromosome
Accession NZ_CP110418
Organism Veillonella rogosae strain KCOM 3468

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OKW85_RS10070 Protein ID WP_265138165.1
Coordinates 2160144..2160554 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C4FMM5
Locus tag OKW85_RS10065 Protein ID WP_005384838.1
Coordinates 2159917..2160147 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKW85_RS10055 (OKW85_10055) 2157304..2158161 + 858 WP_265139135.1 methylenetetrahydrofolate reductase -
OKW85_RS10060 (OKW85_10060) 2158459..2159211 - 753 WP_265138164.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
OKW85_RS10065 (OKW85_10065) 2159917..2160147 + 231 WP_005384838.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OKW85_RS10070 (OKW85_10070) 2160144..2160554 + 411 WP_265138165.1 type II toxin-antitoxin system VapC family toxin Toxin
OKW85_RS10075 (OKW85_10075) 2160630..2162501 - 1872 WP_265138167.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG -
OKW85_RS10080 (OKW85_10080) 2162701..2164086 - 1386 WP_265138169.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
OKW85_RS10085 (OKW85_10085) 2164343..2165143 - 801 WP_265138170.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(9-44)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15320.79 Da        Isoelectric Point: 6.9684

>T263824 WP_265138165.1 NZ_CP110418:2160144-2160554 [Veillonella rogosae]
MKYMLDKNICIYAIKQEPEVVLQKILKHHPSDICISSITYAELMHGVEKSQSKDKNRLALTLLLSPIQIVDFDSHAAEEY
GKIKADLQSQGKVIGPMDLLIASHAKSKGLTIVTNNTKEFERVTQLEVEDWSKPLS

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8660.82 Da        Isoelectric Point: 4.4217

>AT263824 WP_005384838.1 NZ_CP110418:2159917-2160147 [Veillonella rogosae]
MTTAKLFENGRSQAVRLPKEFRFNGDEVIINKIGNVVLLMPKDDEWAGFVAGLSLFTDDFMCNGREDIDHQEREAL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S7YY19

References