263822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 3264527..3265092 Replicon chromosome
Accession NZ_CP110417
Organism Lactiplantibacillus pentosus strain OHF 23

Toxin (Protein)


Gene name mazF Uniprot ID F6IUY4
Locus tag HPK28_RS14915 Protein ID WP_050339912.1
Coordinates 3264745..3265092 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HPK28_RS14910 Protein ID WP_082230320.1
Coordinates 3264527..3264745 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPK28_RS14895 (HPK28_14895) 3260142..3262184 + 2043 WP_056952649.1 KUP/HAK/KT family potassium transporter -
HPK28_RS14900 (HPK28_14900) 3262252..3262899 - 648 WP_225351393.1 N-acetyltransferase -
HPK28_RS14905 (HPK28_14905) 3263038..3263769 - 732 WP_050339911.1 hypothetical protein -
HPK28_RS14910 (HPK28_14910) 3264527..3264745 + 219 WP_082230320.1 hypothetical protein Antitoxin
HPK28_RS14915 (HPK28_14915) 3264745..3265092 + 348 WP_050339912.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HPK28_RS14920 (HPK28_14920) 3265512..3266555 - 1044 WP_021337327.1 AI-2E family transporter -
HPK28_RS14925 (HPK28_14925) 3267008..3268132 + 1125 WP_050339913.1 vitamin B12 independent methionine synthase -
HPK28_RS14930 (HPK28_14930) 3268287..3268670 - 384 WP_050339914.1 multidrug efflux SMR transporter -
HPK28_RS14935 (HPK28_14935) 3268687..3268995 - 309 WP_003639898.1 SMR family transporter -
HPK28_RS14940 (HPK28_14940) 3269371..3270009 - 639 WP_050339915.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13406.29 Da        Isoelectric Point: 9.4892

>T263822 WP_050339912.1 NZ_CP110417:3264745-3265092 [Lactiplantibacillus pentosus]
MTYLPKQKDIIWIDFDPQRGREIKKRRPAVILSSNLYTQNTGFVIVSPITSTIHDLPGYFSLNGYDIHGQVVAAQIYSFD
ARPKAGRNITYIETMRNVDFYRVAQTVYYNFDFPF

Download         Length: 348 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8175.33 Da        Isoelectric Point: 9.6576

>AT263822 WP_082230320.1 NZ_CP110417:3264527-3264745 [Lactiplantibacillus pentosus]
MIEVKTVSRGNSLALSLPKDGRFKKGQRWLLIPSKDGESYTLVPRIENPYAGPKSKQPMTEAWSDVNWNEVE

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F6IUY4

Antitoxin

Source ID Structure

References