Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1480247..1481285 Replicon chromosome
Accession NZ_CP110416
Organism Caldimonas thermodepolymerans strain DSM 15264

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag ONS87_RS07260 Protein ID WP_132765322.1
Coordinates 1480247..1480819 (-) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag ONS87_RS07265 Protein ID WP_132765319.1
Coordinates 1480824..1481285 (-) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONS87_RS07235 (ONS87_07235) 1475468..1475851 - 384 WP_024890396.1 hypothetical protein -
ONS87_RS07240 (ONS87_07240) 1475848..1477227 - 1380 WP_132765332.1 recombinase family protein -
ONS87_RS07245 (ONS87_07245) 1477227..1477670 - 444 WP_132765330.1 DUF2924 domain-containing protein -
ONS87_RS07250 (ONS87_07250) 1477670..1477861 - 192 WP_132765327.1 hypothetical protein -
ONS87_RS07255 (ONS87_07255) 1477966..1480221 - 2256 WP_132765324.1 hypothetical protein -
ONS87_RS07260 (ONS87_07260) 1480247..1480819 - 573 WP_132765322.1 PIN domain-containing protein Toxin
ONS87_RS07265 (ONS87_07265) 1480824..1481285 - 462 WP_132765319.1 helix-turn-helix domain-containing protein Antitoxin
ONS87_RS07270 (ONS87_07270) 1481514..1481777 + 264 WP_132765316.1 DNA-binding protein -
ONS87_RS07275 (ONS87_07275) 1481788..1482282 + 495 WP_132765314.1 hypothetical protein -
ONS87_RS07280 (ONS87_07280) 1482269..1482889 + 621 WP_019562414.1 GIY-YIG nuclease family protein -
ONS87_RS07285 (ONS87_07285) 1482889..1483713 + 825 WP_132765311.1 ATP-binding protein -
ONS87_RS07290 (ONS87_07290) 1483717..1484346 + 630 WP_132765308.1 hypothetical protein -
ONS87_RS07295 (ONS87_07295) 1484358..1484873 + 516 WP_132765305.1 DUF6511 domain-containing protein -
ONS87_RS07300 (ONS87_07300) 1484870..1485616 + 747 WP_132765302.1 hypothetical protein -
ONS87_RS07305 (ONS87_07305) 1485613..1485867 + 255 WP_033371809.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1475848..1525459 49611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

Helix-turn-helix domain, group 17

(83-128)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21488.76 Da        Isoelectric Point: 6.4027

>T263821 WP_132765322.1 NZ_CP110416:c1480819-1480247 [Caldimonas thermodepolymerans]
MSSHFTVVYDACVLYPAPLRDLLMHLALSDLYRARWSDRIHDEWMRNVLASRPDLTAEQLERTRRLMNAHVRDCLVTGFE
YLIASIELPDPSDRHVVAAAIHAGASLIVTFNLKDFPPEALKPYNLAAQHPDDFIVDLLDLHPAGVLEAVARHRRNLKNP
PKSADDYLDTLLAQGLTQSVAVMRPWVMAM

Download         Length: 573 bp

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16931.40 Da        Isoelectric Point: 6.6483

>AT263821 WP_132765319.1 NZ_CP110416:c1481285-1480824 [Caldimonas thermodepolymerans]
MTTPTIPKALPSAEDVALARESGRVLSTVLQTRAETQQIDFHDDKGAVRSVTLPTTALRLLLDVLTEIGQGNAVTVIPIH
AELTTQEAADLLNVSRPFLVQLLEKGEIPFHKIGTHRRVRYQDVIAYKHRIDAERRKALDELAAQAQELGMGY

Download         Length: 462 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References