Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1931232..1931805 Replicon chromosome
Accession NZ_CP110415
Organism Caldimonas thermodepolymerans strain LMG 21645

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ONZ46_RS09180 Protein ID WP_058616348.1
Coordinates 1931518..1931805 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A554XI70
Locus tag ONZ46_RS09175 Protein ID WP_058616347.1
Coordinates 1931232..1931531 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONZ46_RS09135 (ONZ46_09135) 1926235..1927821 + 1587 WP_265137080.1 NAD(P)/FAD-dependent oxidoreductase -
ONZ46_RS09140 (ONZ46_09140) 1927878..1928807 + 930 WP_265137082.1 zinc-binding dehydrogenase -
ONZ46_RS09145 (ONZ46_09145) 1928829..1929071 + 243 WP_265137083.1 hypothetical protein -
ONZ46_RS09150 (ONZ46_09150) 1929450..1929737 + 288 WP_265137085.1 DUF6441 family protein -
ONZ46_RS09155 (ONZ46_09155) 1929741..1930241 - 501 WP_265137086.1 GNAT family N-acetyltransferase -
ONZ46_RS09160 (ONZ46_09160) 1930238..1930519 - 282 WP_265137088.1 DUF1778 domain-containing protein -
ONZ46_RS09165 (ONZ46_09165) 1930609..1930719 - 111 Protein_1812 sterol desaturase family protein -
ONZ46_RS09170 (ONZ46_09170) 1930968..1931111 + 144 Protein_1813 IS110 family transposase -
ONZ46_RS09175 (ONZ46_09175) 1931232..1931531 + 300 WP_058616347.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ONZ46_RS09180 (ONZ46_09180) 1931518..1931805 + 288 WP_058616348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONZ46_RS09185 (ONZ46_09185) 1931874..1931999 + 126 WP_265137092.1 hypothetical protein -
ONZ46_RS09190 (ONZ46_09190) 1932285..1932572 - 288 WP_265137093.1 SRPBCC family protein -
ONZ46_RS09195 (ONZ46_09195) 1932629..1935919 - 3291 WP_265137094.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10862.28 Da        Isoelectric Point: 4.8433

>T263820 WP_058616348.1 NZ_CP110415:1931518-1931805 [Caldimonas thermodepolymerans]
VPELEWSQPARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPEHPRLYRPGRVEGTREMVVRANYIVVYTEDPFTVRI
LRVLHAAQQWPPGQD

Download         Length: 288 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10766.33 Da        Isoelectric Point: 8.8613

>AT263820 WP_058616347.1 NZ_CP110415:1931232-1931531 [Caldimonas thermodepolymerans]
MAAQTSMLHVRVDDKLKAEAAETLATFGLTVSDAVRILLTRVAKEGGLPAGLTADPDAHDAWFRAKVREALADTRPGVPH
QHVMDEAQALIDRKRRARA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A554XI70

References