Detailed information of TA system TA026382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 904129..905009
• Replicon: chromosome
• Accession: NC_017221
• Organism: Bifidobacterium longum subsp. longum KACC 91563

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F8APN2
• Locus tag: BLNIAS_RS03665
• Protein ID: WP_007052625.1
• Coordinates: 904518..905009 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F8APN1
• Locus tag: BLNIAS_RS03660
• Protein ID: WP_007057212.1
• Coordinates: 904129..904521 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLNIAS_RS03655	901285..903984	+	2700	WP_014485554.1	aconitate hydratase AcnA	-
BLNIAS_RS03660	904129..904521	+	393	WP_007057212.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BLNIAS_RS03665	904518..905009	+	492	WP_007052625.1	type II toxin-antitoxin system VapC family toxin	Toxin
BLNIAS_RS03670	905059..907164	-	2106	WP_032736308.1	DUF262 domain-containing protein	-
BLNIAS_RS03675	907254..907895	-	642	WP_014485555.1	GNAT family N-acetyltransferase	-
BLNIAS_RS03680	907935..908660	-	726	WP_014485556.1	response regulator transcription factor	-
BLNIAS_RS03685	908695..909927	-	1233	WP_007056207.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-146)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-61)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18531.70 Da
• Isoelectric Point: 6.2348

>T26382 WP_007052625.1 NC_017221:904518-905009 [Bifidobacterium longum subsp. longum KACC 91563]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Nucleotide

• Length: 492 bp

>T26382 NC_017221:904518-905009 [Bifidobacterium longum subsp. longum KACC 91563]
ATGAGGCAGTCAAAGCAGGTGTCGATCTTGTGCGACACCAATATCCTTATTTATTACATGCTCTGTACGCCTCGGTTCAT
CAAGGATGTCATGAAACTGTTCGAGCGATGCGTCGAGCGGGAGGTAAAGCTGTCCTGTGCGTCACTGTCGCTGAAGGACG
TGTTCTACATCACCCCGGAACGATTCAAAGAACGATTCATGAATGACGAATCCATGGTCGTTGCGACCACCGCCAAGCTG
ATATTGCCGGAGGTGGCATGGTCGGGAATCAGCAAACTCAAGGAGCTCATGACAATCGTGCCGATTGGCGCGGAGGAATG
TGAATTGGCGCAGTCGTTGCGGCACGCGCATAACGATTTCGAGGATGACCTTATTATCGCCGCCGCACAACAATCCGGGG
CCACCTATGTGGTGACGTATGACAAAAAACTAGCCAAGCATTTTCCCGAATATTGCAAAACGCCGGCTGAAATCGTGGCG
GCGCTGGCATAG

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15147.29 Da
• Isoelectric Point: 5.8624

>AT26382 WP_007057212.1 NC_017221:904129-904521 [Bifidobacterium longum subsp. longum KACC 91563]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREAEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Nucleotide

• Length: 393 bp

>AT26382 NC_017221:904129-904521 [Bifidobacterium longum subsp. longum KACC 91563]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAGGCCCGCGAGGCGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGATGAGATAGCTGA
CGAACGGCTGAAGGAATACAGGCATCAGTCGGACTATGCGCGTTATTTGGAGAAGGAGCGGAGTCTGTCATGA

Structures

Toxin

• AlphaFold DB: F8APN2

Antitoxin

• AlphaFold DB: F8APN1