Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4189208..4189862 Replicon chromosome
Accession NZ_CP110404
Organism Shigella sonnei strain S17BD05200

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OKF41_RS21070 Protein ID WP_000244777.1
Coordinates 4189208..4189615 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OKF41_RS21075 Protein ID WP_000354046.1
Coordinates 4189596..4189862 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF41_RS21050 (4185165) 4185165..4186898 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
OKF41_RS21055 (4186904) 4186904..4187614 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OKF41_RS21060 (4187639) 4187639..4188535 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OKF41_RS21065 (4188647) 4188647..4189168 + 522 WP_001055874.1 flavodoxin FldB -
OKF41_RS21070 (4189208) 4189208..4189615 - 408 WP_000244777.1 protein YgfX Toxin
OKF41_RS21075 (4189596) 4189596..4189862 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OKF41_RS21080 (4190105) 4190105..4191085 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
OKF41_RS21085 (4191281) 4191281..4191940 - 660 WP_000250274.1 hemolysin III family protein -
OKF41_RS21090 (4192104) 4192104..4192415 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
OKF41_RS21095 (4192460) 4192460..4193893 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
OKF41_RS21100 (4193950) 4193950..4194693 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T263818 WP_000244777.1 NZ_CP110404:c4189615-4189208 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT263818 WP_000354046.1 NZ_CP110404:c4189862-4189596 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References