Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1437119..1437737 Replicon chromosome
Accession NZ_CP110404
Organism Shigella sonnei strain S17BD05200

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OKF41_RS06975 Protein ID WP_001291435.1
Coordinates 1437119..1437337 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag OKF41_RS06980 Protein ID WP_000344804.1
Coordinates 1437363..1437737 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF41_RS06940 (1432411) 1432411..1432983 + 573 WP_000779812.1 YbaY family lipoprotein -
OKF41_RS06945 (1433014) 1433014..1433325 - 312 WP_000409911.1 MGMT family protein -
OKF41_RS06955 (1433704) 1433704..1434057 + 354 WP_000878140.1 DUF1428 domain-containing protein -
OKF41_RS06960 (1434099) 1434099..1435647 - 1549 Protein_1344 cyclic-guanylate-specific phosphodiesterase PdeB -
OKF41_RS06965 (1435811) 1435811..1436281 - 471 WP_000136192.1 YlaC family protein -
OKF41_RS06970 (1436397) 1436397..1436948 - 552 WP_000102564.1 maltose O-acetyltransferase -
OKF41_RS06975 (1437119) 1437119..1437337 - 219 WP_001291435.1 HHA domain-containing protein Toxin
OKF41_RS06980 (1437363) 1437363..1437737 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
OKF41_RS06985 (1438283) 1438283..1441432 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
OKF41_RS06990 (1441455) 1441455..1442648 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T263809 WP_001291435.1 NZ_CP110404:c1437337-1437119 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT263809 WP_000344804.1 NZ_CP110404:c1437737-1437363 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References