263808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1401558..1402395 Replicon chromosome
Accession NZ_CP110404
Organism Shigella sonnei strain S17BD05200

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag OKF41_RS06795 Protein ID WP_000227784.1
Coordinates 1401558..1402100 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag OKF41_RS06800 Protein ID WP_001297137.1
Coordinates 1402084..1402395 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF41_RS06765 (1396622) 1396622..1397113 + 492 WP_001138904.1 nucleotide binding protein YajQ -
OKF41_RS06770 (1397241) 1397241..1398605 - 1365 WP_001000971.1 MFS transporter -
OKF41_RS06775 (1398724) 1398724..1399421 + 698 WP_237158184.1 IS1-like element IS1A family transposase -
OKF41_RS06780 (1399790) 1399790..1400188 + 399 Protein_1309 SEL1-like repeat protein -
OKF41_RS06790 (1400936) 1400936..1401502 + 567 Protein_1311 SEL1-like repeat protein -
OKF41_RS06795 (1401558) 1401558..1402100 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
OKF41_RS06800 (1402084) 1402084..1402395 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
OKF41_RS06805 (1402580) 1402580..1403470 - 891 WP_000971327.1 heme o synthase -
OKF41_RS06810 (1403482) 1403482..1403811 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
OKF41_RS06815 (1403811) 1403811..1404425 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
OKF41_RS06820 (1404415) 1404415..1406406 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
OKF41_RS06825 (1406428) 1406428..1407375 - 948 WP_265071992.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T263808 WP_000227784.1 NZ_CP110404:c1402100-1401558 [Shigella sonnei]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT263808 WP_001297137.1 NZ_CP110404:c1402395-1402084 [Shigella sonnei]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References